We study the dynamic determinants of co-transcriptional gene regulation across species, individuals, tissues, and cells

Our lab uses a combination of high-throughput, functional genomics, bioinformatics and molecular approaches to study the co-transcriptional gene regulation of mammalian expression programs.

Recent highlights

Exon-Mediated Activation of Transcription Starts

Splicing of internal exons activates proximal upstream weak promoters

Widespread occurrence of hybrid internal-terminal exons in human transcriptomes

The HIT index identified thousands of previously misclassified hybrid first-internal and internal-last exons

Splicing activates transcription from weak promoters upstream of alternative exons

Splicing-switching ASOs can regulate gene expression in human genes

mRNA initiation and termination are spatially coordinated

mRNA 5’ end choice directly influences mRNA 3’ ends